LongevityMap Gene
Gene details
- HGNC symbol
- PEBP4
- Aliases
- CORK1; CORK-1; PEBP-4; hPEBP4; PRO4408; GWTM1933; HEL-S-300
- Common name
- phosphatidylethanolamine binding protein 4
- Description
- The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]
- Cytogenetic Location
- 8p21.3
- UCSC Genome Browser
- View 8p21.3 on the UCSC genome browser
- OMIM
- 612473
- Ensembl
- ENSG00000134020
- UniProt/Swiss-Prot
- PEBP4_HUMAN
- Entrez Gene
- 157310
- UniGene
- 491242
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- F40A3.3
- Caenorhabditis elegans
- Y69E1A.5
- Drosophila melanogaster
- a5
- Drosophila melanogaster
- CG30060
- Drosophila melanogaster
- CG7054
- Drosophila melanogaster
- Pebp1
- Drosophila melanogaster
- CG6180
- Drosophila melanogaster
- CG17919
- Drosophila melanogaster
- CG17917
- Drosophila melanogaster
- CG10298
- Mus musculus
- Pebp4
- Saccharomyces cerevisiae
- 850876
- Saccharomyces cerevisiae
- TFS1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
- Conclusions
- No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.
- Indentifier
- rs7005993
- Reference