LongevityMap Gene
Gene details
- HGNC symbol
- PCNX2
- Aliases
- PCNXL2
- Common name
- pecanex homolog 2 (Drosophila)
- Description
- This gene contains coding mononucleotide repeats that are associated with tumors of high mcrosatellite instability (MSI-H). Defects in this gene are involved in the tumorigenesis of MSI-H colorectal carcinomas. [provided by RefSeq, Jun 2016]
- Cytogenetic Location
- 1q42.2
- UCSC Genome Browser
- View 1q42.2 on the UCSC genome browser
- OMIM
- Ensembl
- ENSG00000135749
- UniProt/Swiss-Prot
- B3KNZ5_HUMAN
- Entrez Gene
- 80003
- UniGene
- 370605
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- B0511.12
- Danio rerio
- pcnxl2
- Drosophila melanogaster
- pcx
- Mus musculus
- Pcnx2
- Rattus norvegicus
- Pcnx2
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs701176
- Reference