LongevityMap Gene
Gene details
- HGNC symbol
- NEIL2
- Aliases
- NEH2; NEI2
- Common name
- nei like DNA glycosylase 2
- Description
- This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]
- Cytogenetic Location
- 8p23.1
- UCSC Genome Browser
- View 8p23.1 on the UCSC genome browser
- OMIM
- 608933
- Ensembl
- ENSG00000154328
- UniProt/Swiss-Prot
- A0A024R361_HUMAN
- Entrez Gene
- 252969
- UniGene
- 293818
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs1043180
- Reference