LongevityMap Gene

Gene details

HGNC symbol: MYT1L
Aliases: NZF1; MRD39; myT1-L; ZC2H2C2; ZC2HC4B
Common name: myelin transcription factor 1 like
Description: This gene encodes a member of the zinc finger superfamily of transcription factors. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with autosomal mental retardation-39 and autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
Cytogenetic Location: 2p25.3
UCSC Genome Browser: View 2p25.3 on the UCSC genome browser
OMIM: 613084
Ensembl: ENSG00000186487
UniProt/Swiss-Prot: MYT1L_HUMAN
Entrez Gene: 23040
UniGene: 434418
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

rs10190125

Reference