LongevityMap Gene

Gene details

HGNC symbol: MYO9B
Aliases: MYR5; CELIAC4
Common name: myosin IXB
Description: This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Cytogenetic Location: 19p13.11
UCSC Genome Browser: View 19p13.11 on the UCSC genome browser
OMIM: 602129
Ensembl: ENSG00000099331
UniProt/Swiss-Prot: B0I1T6_HUMAN
Entrez Gene: 4650
UniGene: 123198
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

rs7246865

Reference