LongevityMap Gene
Gene details
- HGNC symbol
- MYLIP
- Aliases
- MIR; IDOL
- Common name
- myosin regulatory light chain interacting protein
- Description
- The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 6p22.3
- UCSC Genome Browser
- View 6p22.3 on the UCSC genome browser
- OMIM
- 610082
- Ensembl
- ENSG00000007944
- UniProt/Swiss-Prot
- MYLIP_HUMAN
- Entrez Gene
- 29116
- UniGene
- 484738
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- frm-4
- Caenorhabditis elegans
- F52D10.6
- Danio rerio
- mylipa
- Danio rerio
- mylipb
- Drosophila melanogaster
- dnr1
- Mus musculus
- Mylip
- Rattus norvegicus
- Mylip
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study for longevity-related traits in up to 1345 Framingham Study participants from 330 families; 713 participants achieved age 65 years or greater. A total of 79 potential candidate genes and regions associated with longevity were also studied.
- Conclusions
- Although no genome-wide associations were significant, mutiple SNPs and genes had suggestive associations with age at death
- Indentifier
- rs3757354
- Reference