LongevityMap Gene
Gene details
- HGNC symbol
- MYH7B
- Aliases
- MHC14; MYH14
- Common name
- myosin heavy chain 7B
- Description
- The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]
- Cytogenetic Location
- 20q11.22
- UCSC Genome Browser
- View 20q11.22 on the UCSC genome browser
- OMIM
- 609928
- Ensembl
- ENSG00000078814
- UniProt/Swiss-Prot
- MYH7B_HUMAN
- Entrez Gene
- 57644
- UniGene
- 414122
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- myo-5
- Caenorhabditis elegans
- unc-54
- Caenorhabditis elegans
- myo-6
- Caenorhabditis elegans
- myo-3
- Caenorhabditis elegans
- myo-1
- Danio rerio
- myh7bb
- Danio rerio
- myh7ba
- Drosophila melanogaster
- Mhc
- Mus musculus
- Myh7b
- Rattus norvegicus
- Myh7b
- Saccharomyces cerevisiae
- MYO1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Indentifier
- rs6088662
- Reference