LongevityMap Gene
Gene details
- HGNC symbol
- MTHFD1L
- Aliases
- FTHFSDC1; MTC1THFS; dJ292B18.2
- Common name
- methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
- Description
- The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
- Cytogenetic Location
- 6q25.1
- UCSC Genome Browser
- View 6q25.1 on the UCSC genome browser
- OMIM
- 611427
- Ensembl
- ENSG00000120254
- UniProt/Swiss-Prot
- A0A087WVM4_HUMAN
- Entrez Gene
- 25902
- UniGene
- 591343
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- K07E3.4
- Danio rerio
- mthfd1l
- Drosophila melanogaster
- pug
- Mus musculus
- Mthfd1l
- Rattus norvegicus
- Mthfd1l
- Saccharomyces cerevisiae
- MIS1
- Schizosaccharomyces pombe
- ade9
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as MIS1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- A set of alleles associated with age-related diseases was tested for association with human longevity in 723 nonagenarian siblings and 721 unrelated younger controls plus 979 singleton individuals >85 years of age and 1,167 younger controls
- Conclusions
- No differences were observed in disease risk allele frequency between long-lived individuals and controls. No individual allele was significantly associated with survival to old age after controlling for multiple testing.
- Indentifier
- rs6922269
- Reference