LongevityMap Gene

Gene details

HGNC symbol: MT1A
Aliases: MT1; MTC; MT1S
Common name: metallothionein 1A
Description
Cytogenetic Location: 16q13
UCSC Genome Browser: View 16q13 on the UCSC genome browser
OMIM: 156350
Ensembl: ENSG00000205362
UniProt/Swiss-Prot: MT1A_HUMAN
Entrez Gene: 4489
UniGene: 655199
1000 Genomes: 1000 Genomes

Homologs in model organisms

Mus musculus: Mt2
Rattus norvegicus: Mt1m
Rattus norvegicus: Mt2A

In other databases

GenAge microarray genes

This gene is present as MT1A

GenDR gene expression

A homolog of this gene for Mus musculus is present as Mt2

Studies (2)

Significant/Non-significant: 1/1

Study 1

Longevity Association

Population

Study Design

Polymorphisms A/C (Asp/Thr) transition at 647 nt position and A/G (Lys/Arg) transition at 1,245 nt position were examined in 251 old and very old females

Conclusions

For the +647 polymorphism significant differences were observed between old and very old females. Females with Asp/Asp genotype display reduced IL-6 plasma concentrations.

Indentifier

Reference

Study 2

Longevity Association: Non-significant
Population: Danish
Study Design: 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
Conclusions: No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
Indentifier