LongevityMap Gene
Gene details
- HGNC symbol
- MS4A6A
- Aliases
- CDA01; MS4A6; 4SPAN3; CD20L3; MST090; MSTP090; 4SPAN3.2
- Common name
- membrane spanning 4-domains A6A
- Description
- This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. [provided by RefSeq, Oct 2011]
- Cytogenetic Location
- 11q12.2
- UCSC Genome Browser
- View 11q12.2 on the UCSC genome browser
- OMIM
- 606548
- Ensembl
- ENSG00000110077
- UniProt/Swiss-Prot
- A0A024R516_HUMAN
- Entrez Gene
- 64231
- UniGene
- 523702
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Mus musculus
- Ms4a6c
- Mus musculus
- Ms4a6b
- Mus musculus
- Ms4a6d
- Rattus norvegicus
- Ms4a6bl
- Rattus norvegicus
- Ms4a6e
- Rattus norvegicus
- Ms4a6a
- Rattus norvegicus
- Ms4a6e
- Rattus norvegicus
- Ms4a6c
- Rattus norvegicus
- Ms4a6bl
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Apart APOE, no variants appeared to be associated with aging with a genome-wide level of significance
- Indentifier
- rs610932
- Reference