LongevityMap Gene
Gene details
- HGNC symbol
- MOB3B
- Aliases
- MOB1D; C9orf35; MOBKL2B
- Common name
- MOB kinase activator 3B
- Description
- The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 9p21.2
- UCSC Genome Browser
- View 9p21.2 on the UCSC genome browser
- OMIM
- Ensembl
- ENSG00000120162
- UniProt/Swiss-Prot
- MOB3B_HUMAN
- Entrez Gene
- 79817
- UniGene
- 369022
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- T12B3.4
- Drosophila melanogaster
- Mob3
- Mus musculus
- Mob3b
- Rattus norvegicus
- Mob3b
- Saccharomyces cerevisiae
- MOB1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Some signals were at best tentative but may merit study in larger sample sets
- Indentifier
- rs1555453
- Reference