LongevityMap Gene
Gene details
- HGNC symbol
- MMP3
- Aliases
- SL-1; STMY; STR1; CHDS6; MMP-3; STMY1
- Common name
- matrix metallopeptidase 3
- Description
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 11q22.2
- UCSC Genome Browser
- View 11q22.2 on the UCSC genome browser
- OMIM
- 185250
- Ensembl
- ENSG00000149968
- UniProt/Swiss-Prot
- MMP3_HUMAN
- Entrez Gene
- 4314
- UniGene
- 375129
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- CellAge gene expression
- This gene is present as MMP3
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Japanese
- Study Design
- -1171 5A/6A SNP was evaluated with age or gender in 500 Japanese persons (mean age: 56.7 years old, range: 19-100)
- Conclusions
- -1171 5A/6A polymorphism is gender age associated but not in a significant manner
- Indentifier
- -1171 5A/6A
- Reference