LongevityMap Gene

Gene details

HGNC symbol: MINPP1
Aliases: MIPP; HIPER1; MINPP2
Common name: multiple inositol-polyphosphate phosphatase 1
Description: This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]
Cytogenetic Location: 10q23.2
UCSC Genome Browser: View 10q23.2 on the UCSC genome browser
OMIM: 605391
Ensembl: ENSG00000107789
UniProt/Swiss-Prot: MINP1_HUMAN
Entrez Gene: 9562
UniGene: 121260
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: minpp1a
Drosophila melanogaster: Mipp1
Mus musculus: Minpp1
Rattus norvegicus: RGD1564801
Saccharomyces cerevisiae: DIA3
Schizosaccharomyces pombe: pho1

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Caucasians

Study Design

Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).

Conclusions

There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance (5 × 10-8) after correcting for multiple testing. One association for rs9664222 (near MINPP1), reached 6.77 × 10-7 for the combined meta-analysis.

Indentifier

rs9664222

Reference