LongevityMap Gene
Gene details
- HGNC symbol
- METTL1
- Aliases
- TRM8; TRMT8; C12orf1; YDL201w
- Common name
- methyltransferase like 1
- Description
- This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 12q14.1
- UCSC Genome Browser
- View 12q14.1 on the UCSC genome browser
- OMIM
- 604466
- Ensembl
- ENSG00000037897
- UniProt/Swiss-Prot
- TRMB_HUMAN
- Entrez Gene
- 4234
- UniGene
- 42957
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- W02B12.10
- Danio rerio
- mettl1
- Drosophila melanogaster
- CG4045
- Mus musculus
- Mettl1
- Rattus norvegicus
- Mettl1
- Saccharomyces cerevisiae
- TRM8
- Schizosaccharomyces pombe
- trm8
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American
- Study Design
- A genome-wide linkage scan was performed for healthy aging in family study data, followed by fine-mapping by association in a separate population. A frailty index, called FI34, was introduced as a quantitative measure of healthy aging.
- Conclusions
- A single linkage peak was found on chromosome 12 in the genome-wide linkage scan. Fine-scale association mapping identified three sites associated with healthy aging in intergenic regions at 12q13-14.
- Indentifier
- rs10877013
- Reference