LongevityMap Gene
Gene details
- HGNC symbol
- MECOM
- Aliases
- EVI1; MDS1; KMT8E; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1
- Common name
- MDS1 and EVI1 complex locus
- Description
- The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
- Cytogenetic Location
- 3q26.2
- UCSC Genome Browser
- View 3q26.2 on the UCSC genome browser
- OMIM
- 165215
- Ensembl
- ENSG00000085276
- UniProt/Swiss-Prot
- A0A0C3SFZ7_HUMAN
- Entrez Gene
- 2122
- UniGene
- 744090
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- egl-43
- Danio rerio
- mecom
- Mus musculus
- Mecom
- Rattus norvegicus
- Mecom
- Saccharomyces cerevisiae
- COM2
- Saccharomyces cerevisiae
- MSN2
- Saccharomyces cerevisiae
- MSN4
In other databases
- GenDR gene manipulations
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- European
- Study Design
- Meta-analysis of genome-wide association studies of survival and survival free of major disease or death. In total, there were 25,007 participants over 55 years of age and followed-up for over 10 years for mortality and over 8 years for event-free survival.
- Conclusions
- No SNP was significantly associated with time to event after correcting for multiple testing, but 8 independent SNPs predicted event-free survival at a suggestive threshold
- Indentifier
- rs16852912
- Reference