LongevityMap Gene

Gene details

HGNC symbol: LYPD6
Aliases
Common name: LY6/PLAUR domain containing 6
Description: Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010]
Cytogenetic Location: 2q23.2
UCSC Genome Browser: View 2q23.2 on the UCSC genome browser
OMIM: 613359
Ensembl: ENSG00000187123
UniProt/Swiss-Prot: LYPD6_HUMAN
Entrez Gene: 130574
UniGene: 21929
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: lypd6
Mus musculus: Lypd6
Rattus norvegicus: Lypd6

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Caucasians

Study Design

Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).

Conclusions

There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing

Indentifier

rs1420356

Reference