LongevityMap Gene
Gene details
- HGNC symbol
- LYN
- Aliases
- JTK8; p53Lyn; p56Lyn
- Common name
- LYN proto-oncogene, Src family tyrosine kinase
- Description
- This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
- Cytogenetic Location
- 8q12.1
- UCSC Genome Browser
- View 8q12.1 on the UCSC genome browser
- OMIM
- 165120
- Ensembl
- ENSG00000254087
- UniProt/Swiss-Prot
- A8K379_HUMAN
- Entrez Gene
- 4067
- UniGene
- 491767
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- src-1
- Danio rerio
- lyn
- Drosophila melanogaster
- Src64B
- Mus musculus
- Lyn
- Rattus norvegicus
- Lyn
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Korean
- Study Design
- 463 biomarkers in 176 diesase associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
- Conclusions
- LYN was associated with longevity (P = 0.002) after correcting for multiple hypothesis testing
- Indentifier
- rs1450740
- Reference