LongevityMap Gene

Gene details

HGNC symbol: LRP1B
Aliases: LRP-1B; LRPDIT; LRP-DIT
Common name: LDL receptor related protein 1B
Description: This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]
Cytogenetic Location: 2q22.1-q22.2
UCSC Genome Browser: View 2q22.1-q22.2 on the UCSC genome browser
OMIM: 608766
Ensembl: ENSG00000168702
UniProt/Swiss-Prot: LRP1B_HUMAN
Entrez Gene: 53353
UniGene: 656461
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/1

Longevity Association: Non-significant
Population: Dutch
Study Design: Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
Conclusions: No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.
Indentifier

Longevity Association: Significant
Population: American (Caucasian)
Study Design: Genome-wide association study in 801 centenarians and 914 healthy controls
Conclusions: 281 SNPs were found to discriminate between cases and controls
Indentifier