LongevityMap Gene
Gene details
- HGNC symbol
- LOX
- Aliases
- AAT10
- Common name
- lysyl oxidase
- Description
- This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
- Cytogenetic Location
- 5q23.1
- UCSC Genome Browser
- View 5q23.1 on the UCSC genome browser
- OMIM
- 153455
- Ensembl
- ENSG00000113083
- UniProt/Swiss-Prot
- B0AZT2_HUMAN
- Entrez Gene
- 4015
- UniGene
- 102267
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- LOX (1 of many)
- Danio rerio
- loxa
- Drosophila melanogaster
- lox
- Mus musculus
- Lox
- Rattus norvegicus
- Lox
In other databases
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Indentifier
- rs17352686
- Reference