LongevityMap Gene
Gene details
- HGNC symbol
- LIG3
- Aliases
- LIG2
- Common name
- DNA ligase 3
- Description
- This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 17q12
- UCSC Genome Browser
- View 17q12 on the UCSC genome browser
- OMIM
- 600940
- Ensembl
- ENSG00000005156
- UniProt/Swiss-Prot
- DNLI3_HUMAN
- Entrez Gene
- 3980
- UniGene
- 100299
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- lig-1
- Danio rerio
- lig3
- Drosophila melanogaster
- lig3
- Mus musculus
- Lig3
- Rattus norvegicus
- Lig3
- Saccharomyces cerevisiae
- CDC9
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs2074516
- Reference