LongevityMap Gene
Gene details
- HGNC symbol
- LIG1
- Aliases
- Common name
- DNA ligase 1
- Description
- This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- Cytogenetic Location
- 19q13.33
- UCSC Genome Browser
- View 19q13.33 on the UCSC genome browser
- OMIM
- 126391
- Ensembl
- ENSG00000105486
- UniProt/Swiss-Prot
- B4DM52_HUMAN
- Entrez Gene
- 3978
- UniGene
- 1770
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- lig1
- Drosophila melanogaster
- DNA-ligI
- Mus musculus
- Lig1
- Rattus norvegicus
- LOC100911727
- Rattus norvegicus
- Lig1
- Saccharomyces cerevisiae
- CDC9
- Schizosaccharomyces pombe
- cdc17
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs274860
- Reference