LongevityMap Gene
Gene details
- HGNC symbol
- KLRF1
- Aliases
- NKp80; CLEC5C
- Common name
- killer cell lectin like receptor F1
- Description
- KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]
- Cytogenetic Location
- 12p13.31
- UCSC Genome Browser
- View 12p13.31 on the UCSC genome browser
- OMIM
- 605029
- Ensembl
- ENSG00000150045
- UniProt/Swiss-Prot
- A0A0C4DFN7_HUMAN
- Entrez Gene
- 51348
- UniGene
- 183125
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
No homologs found
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs2232548
- Reference