LongevityMap Gene
Gene details
- HGNC symbol
- KCNMA1
- Aliases
- SLO; BKTM; SLO1; hSlo; MaxiK; SAKCA; mSLO1; KCa1.1; SLO-ALPHA; bA205K10.1
- Common name
- potassium calcium-activated channel subfamily M alpha 1
- Description
- MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 10q22.3
- UCSC Genome Browser
- View 10q22.3 on the UCSC genome browser
- OMIM
- 600150
- Ensembl
- ENSG00000156113
- UniProt/Swiss-Prot
- A0A087WZL8_HUMAN
- Entrez Gene
- 3778
- UniGene
- 144795
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- slo-1
- Danio rerio
- kcnma1a
- Drosophila melanogaster
- slo
- Mus musculus
- Kcnma1
- Rattus norvegicus
- Kcnma1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
- Conclusions
- No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.
- Indentifier
- rs1516507
- Reference