LongevityMap Gene
Gene details
- HGNC symbol
- KARS
- Aliases
- KRS; KARS1; KARS2; CMTRIB; DFNB89
- Common name
- lysyl-tRNA synthetase
- Description
- Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 16q23.1
- UCSC Genome Browser
- View 16q23.1 on the UCSC genome browser
- OMIM
- 601421
- Ensembl
- ENSG00000065427
- UniProt/Swiss-Prot
- SYK_HUMAN
- Entrez Gene
- 3735
- UniGene
- 3100
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- kars-1
- Danio rerio
- kars
- Drosophila melanogaster
- Aats-lys
- Mus musculus
- Kars
- Rattus norvegicus
- Kars
- Saccharomyces cerevisiae
- KRS1
- Schizosaccharomyces pombe
- krs1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs1865493
- Reference