LongevityMap Gene
Gene details
- HGNC symbol
- ITGA1
- Aliases
- VLA1; CD49a
- Common name
- integrin subunit alpha 1
- Description
- This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 5q11.2
- UCSC Genome Browser
- View 5q11.2 on the UCSC genome browser
- OMIM
- 192968
- Ensembl
- ENSG00000213949
- UniProt/Swiss-Prot
- ITA1_HUMAN
- Entrez Gene
- 3672
- UniGene
- 644352
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- itga1
- Drosophila melanogaster
- ItgalphaPS5
- Drosophila melanogaster
- ItgalphaPS4
- Drosophila melanogaster
- scb
- Mus musculus
- Itga1
- Rattus norvegicus
- Itga1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs2432143
- Reference