LongevityMap Gene

Gene details

HGNC symbol: IL6R
Aliases: IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1
Common name: interleukin 6 receptor
Description: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]
Cytogenetic Location: 1q21.3
UCSC Genome Browser: View 1q21.3 on the UCSC genome browser
OMIM: 147880
Ensembl: ENSG00000160712
UniProt/Swiss-Prot: A0A087WTB5_HUMAN
Entrez Gene: 3570
UniGene: 135087
1000 Genomes: 1000 Genomes

Significant/Non-significant: 0/2

Longevity Association: Non-significant
Population: Danish, German, Dutch
Study Design: 102 SNPs from 16 longevity candidate genes were examined in Danish. 1089 individuals (ages 92.2-93.8, mean age 93.2, 71.3 female) and 736 middle-aged controls (46-55 y, mean age 50.6, 49.6% female) were involved in this case-control study. Then the results were replicated in a German cohort of 1613 individuals (95-110 y, 73.2% female) and 1104 middle-aged controls (mean age 67.2, SD 4.07, 74.3% female). A 11 years study was introduced in Danish cohort to identify the SNPs associated with longevity, then the results were verified in Dutch longitudinal cohort.
Conclusions: After correcting for multiple testing, no SNPs were significantly associated with longevity, except in APOE and CETP. rs4343 (ACE) was nominally significantly associated with longevity (P < 0.05).
Indentifier

Longevity Association: Non-significant
Population: American (Caucasian and African–American), Ashkenazi Jewish
Study Design: A panel of 477 tag SNPs across 87 candidate genes was screened in >5000 older participants from the population-based Cardiovascular Health Study (CHS). Then, the significant results were validated in Ashkenazi Jews cohort and Study of Osteoporotic Fractures (SOF) cohort.
Conclusions: Although baseline IL-6 concentration was a strong predictor of mortality, and IL6R alleles were associated with IL-6, there was no evidence of association between IL6R alleles and longevity
Indentifier