LongevityMap Gene
Gene details
- HGNC symbol
- IGF2BP2
- Aliases
- IMP2; IMP-2; VICKZ2
- Common name
- insulin like growth factor 2 mRNA binding protein 2
- Description
- This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
- Cytogenetic Location
- 3q27.2
- UCSC Genome Browser
- View 3q27.2 on the UCSC genome browser
- OMIM
- 608289
- Ensembl
- ENSG00000073792
- UniProt/Swiss-Prot
- B3FTN5_HUMAN
- Entrez Gene
- 10644
- UniGene
- 35354
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- zbp-1
- Danio rerio
- igf2bp2a
- Danio rerio
- igf2bp2b
- Drosophila melanogaster
- Imp
- Mus musculus
- Igf2bp2
- Rattus norvegicus
- Igf2bp2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- A set of alleles associated with age-related diseases was tested for association with human longevity in 723 nonagenarian siblings and 721 unrelated younger controls plus 979 singleton individuals >85 years of age and 1,167 younger controls
- Conclusions
- No differences were observed in disease risk allele frequency between long-lived individuals and controls. No individual allele was significantly associated with survival to old age after controlling for multiple testing.
- Indentifier
- rs4402960
- Reference