LongevityMap Gene

Gene details

HGNC symbol: IGF2
Aliases: GRDF; IGF-II; PP9974; C11orf43
Common name: insulin like growth factor 2
Description: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Cytogenetic Location: 11p15.5
UCSC Genome Browser: View 11p15.5 on the UCSC genome browser
OMIM: 147470
Ensembl: ENSG00000167244
UniProt/Swiss-Prot: E3UN46_HUMAN
Entrez Gene: 3481
UniGene: 272259
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: igf2b
Danio rerio: igf2a
Mus musculus: Igf2
Rattus norvegicus: Igf2

In other databases

GenAge human genes

This gene is present as IGF2

Studies (5)

Significant/Non-significant: 2/3

Study 1

Longevity Association

Non-significant

Population

Study Design

Exon 9 AvaII RFLP polymorphism was examined in 219 centenarians (72 males and 147 females) and 256 (controls 20-70 years, 119 males and 137 females)

Conclusions

No significant difference between centenarians and controls was observed

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Reference

Study 2

Longevity Association

Population

Ashkenazi Jewish (Jerusalem)

Study Design

A/G ApaI site SNP was examined in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity (150 males and 74 females) and a group of 441 younger subjects (22 years)

Conclusions

An increase in the A allele was observed in older Ashkenazi females and a highly significant increase was observed in the AA genotype in these subjects

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Reference

Study 3

Longevity Association

Population

Study Design

Studied genetic variation in the insulin/insulin-like growth factor signaling (IIS) pathway and in the telomere maintenance pathway for associations with longevity in 403 unrelated nonagenarians and 1,670 younger controls

Conclusions

SNP sets in both pathways were associated with longevity with the association of the IIS pathway defined by several genes (AKT1, AKT3, FOXO4, IGF2, INS, PIK3CA, SGK, SGK2, and YWHAG), while the telomere maintenance pathway seemed to be mainly determined by POT1 since only these genes showed an association with longevity

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Reference

Study 4

Longevity Association

Non-significant

Population

Study Design

The chromosomal region 11p.15.5 was investigated in 1321 centenarians and 1140 younger subjects from European samples

Conclusions

No significant results were observed for genes previously associated with longevity: TH, IGF2, INS and HRAS1

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Reference

Study 5

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
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