LongevityMap Gene

Gene details

HGNC symbol: HSPA1A
Aliases: HSP72; HSPA1; HSP70I; HSP70-1; HSP70.1; HSP70-1A; HEL-S-103
Common name: heat shock protein family A (Hsp70) member 1A
Description: This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 6p21.33
UCSC Genome Browser: View 6p21.33 on the UCSC genome browser
OMIM: 140550
Ensembl: ENSG00000204389
UniProt/Swiss-Prot: A8K5I0_HUMAN
Entrez Gene: 3303
UniGene: 274402
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: hsp-1
Danio rerio: hsp70l
Danio rerio: hsp70.3
Danio rerio: si:ch211-199o1.2
Drosophila melanogaster: Hsc70-4
Drosophila melanogaster: Hsc70-1
Mus musculus: Hspa1a
Mus musculus: Hspa1b
Rattus norvegicus: Hspa1b
Rattus norvegicus: Hspa1a
Rattus norvegicus: Hspa1a
Rattus norvegicus: Hspa1b
Saccharomyces cerevisiae: SSA1

In other databases

GenAge human genes

This gene is present as HSPA1A

CellAge

This gene is present as HSPA1A

Studies (8)

Significant/Non-significant: 5/3

Study 1

Longevity Association

Population

Italian (Southern)

Study Design

(A/C)-110 polymorphism was examined in 591 subjects (263 males and 328 females; age range 18-109 years; 36 male and 84 female centenarians)

Conclusions

A significant age-related decrease of the frequency of allele (A)-110 was observed in females, while no difference was observed in the males

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Reference

Study 2

Longevity Association

Population

Study Design

The -110A/C polymorphism was examined in a cohort of aged Danish twins (individuals aged between 70 and 91 years, categorized according to the presence or absence of various diseases)

Conclusions

An association was found between low self-rated health and heterozygosity (AC genotype)

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Reference

Study 3

Longevity Association

Population

Study Design

The A/C -110 polymorphism was examined in 426 participants of various ages

Conclusions

Female carriers of CC genotype survive better than the noncarriers (AA and AC)

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Reference

Study 4

Longevity Association: Non-significant
Population: Ashkenazi Jewish
Study Design: Polymorphisms were examined in 347 centenarians, 260 centenarian offspring, and 238 controls
Conclusions: No genetic associations were found with two SNPs within two hsp70 genes
Indentifier

Study 5

Longevity Association

Population

Chinese (Uighur in Xinjiang)

Study Design

Case-control study in 191 healthy individuals greater than 90 years of age, and 53 naturally died persons 65-70 years of age on A1267G in HSPA1B, G190C in HSPA1A, and T2437C in HSPA1L

Conclusions

In single-locus analysis, no significant differences were found between long-lived people and short-lived people in the genotype/allele distributions of all variants. In contrast, haplotype analysis indicated that haplotypes A-G-C and A-C-T were more prevalent in long-lived people than short-lived people (P=0.026 and 0.017), and the analysis conferred a 3.46- and 4.51-fold increased tendency for longevity, respectively (P=0.025 and 0.016).

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Reference

Study 6

Longevity Association

Population

Study Design

Three single nucleotide polymorphisms, HSPA1A (-110A>C), HSPA1B (1267A>G), and HSPA1L (2437T>C), present in the three HSP70 genes, were studied in a cohort of individuals born in the year 1905.

Conclusions

A significant association of HSPA1A-AA (RR=3.864; p=0.016) and HSPA1B-AA (RR=2.764; p=0.039) genotypes with poor survival was observed in female subjects. Also the female carriers of haplotype G-C-T had longer survival than the non-carriers (HRR=0.550; p=0.015). On an average, female carriers of the G-C-T haplotype live about one year longer than non-carriers.

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Reference

Study 7

Longevity Association: Non-significant
Population: Danish, German, Dutch
Study Design: 102 SNPs from 16 longevity candidate genes were examined in Danish. 1089 individuals (ages 92.2-93.8, mean age 93.2, 71.3 female) and 736 middle-aged controls (46-55 y, mean age 50.6, 49.6% female) were involved in this case-control study. Then the results were replicated in a German cohort of 1613 individuals (95-110 y, 73.2% female) and 1104 middle-aged controls (mean age 67.2, SD 4.07, 74.3% female). A 11 years study was introduced in Danish cohort to identify the SNPs associated with longevity, then the results were verified in Dutch longitudinal cohort.
Conclusions: After correcting for multiple testing, no SNPs were significantly associated with longevity, except in APOE and CETP. rs4343 (ACE) was nominally significantly associated with longevity (P < 0.05).
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Study 8

Longevity Association: Non-significant
Population: American (Caucasian), Ashkenazi Jewish
Study Design: Serum Hsp70 levels and hsp70 genes variants were analyzed in a sample (from New England Centenarian Study (NECS) or the Longevity Genes Project (LGP)) of centenarian subjects, their offspring, and unrelated controls to study the associations with longevity.
Conclusions: Adjusted Hsp70 levels are significantly lower in NECS offspring than in NECS controls (sex-adjusted p < 0.001) and there is a trend towards lower Hsp70 among LGP centenarians when compared to LGP controls (age-adjusted p = 0.058). No genetic associations were found with two SNPs within two hsp70 genes.
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