LongevityMap Gene

Gene details

HGNC symbol: HS3ST3B1
Aliases: 3OST3B1; 3-OST-3B; h3-OST-3B
Common name: heparan sulfate-glucosamine 3-sulfotransferase 3B1
Description: The protein encoded by this gene is a type II integral membrane protein that belongs to the 3-O-sulfotransferases family. These proteins catalyze the addition of sulfate groups at the 3-OH position of glucosamine in heparan sulfate. The substrate specificity of individual members of the family is based on prior modification of the heparan sulfate chain, thus allowing different members of the family to generate binding sites for different proteins on the same heparan sulfate chain. Following treatment with a histone deacetylase inhibitor, expression of this gene is activated in a pancreatic cell line. The increased expression results in promotion of the epithelial-mesenchymal transition. In addition, the modification catalyzed by this protein allows herpes simplex virus membrane fusion and penetration. A very closely related homolog with an almost identical sulfotransferase domain maps less than 1 Mb away. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Cytogenetic Location: 17p12
UCSC Genome Browser: View 17p12 on the UCSC genome browser
OMIM: 604058
Ensembl: ENSG00000125430
UniProt/Swiss-Prot: HS3SB_HUMAN
Entrez Gene: 9953
UniGene: 48384
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

rs1005321

Reference