LongevityMap Gene

Gene details

HGNC symbol: HLA-B
Aliases: AS; HLAB; B-4901
Common name: major histocompatibility complex, class I, B
Description: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 6p21.33
UCSC Genome Browser: View 6p21.33 on the UCSC genome browser
OMIM: 142830
Ensembl: ENSG00000234745
UniProt/Swiss-Prot: 1B07_HUMAN
Entrez Gene: 3106
UniGene: 77961
1000 Genomes: 1000 Genomes

Homologs in model organisms

Rattus norvegicus: RT1-T24-4
Rattus norvegicus: RT1-T24-3
Rattus norvegicus: RT1-T24-2
Rattus norvegicus: RT1-T24-1

In other databases

CellAge gene expression

This gene is present as HLA-B

Studies (4)

Significant/Non-significant: 0/4

Study 1

Longevity Association

Non-significant

Population

Study Design

964 inhabitants aged 85 years and over and 2444 young controls, aged 20-35 years, with an identical ethnic and demographic background were examined

Conclusions

Without correcting for multiple testing, HLA-B40 was lower in the group of 85 years and over, as compared to the control group

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Irish (Belfast)

Study Design

100 control samples (59% female, 41% male with an age-range of 19-45 years old) and 93 aged samples (70% female, 30% male with an age-range of 80-97 years old) were examined

Conclusions

No age-related allele or genotype frequencies were observed

Indentifier

Reference

Study 3

Longevity Association

Non-significant

Population

Study Design

14 alleles were examined in 17 unrelated elderly (age 65-90 years; 6 males and 11 females), 23 family members (age 18-57 years; 9 males and 14 females), and a control group with 105 randomly selected, matched for geographical distribution healthy controls aged 25-53 years (40 male and 65 female)

Conclusions

The most frequent HLB alleles in elderly Bulgarians were B18 and B*51, though differences were not statistically significant after correcting for multiple testing

Indentifier

Reference

Study 4

Longevity Association

Non-significant

Population

Study Design

71 healthy elders were studied, ages ranged from 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 - 54 years; mean 35.2 years) healthy individuals unrelated to elders.

Conclusions

The frequencies of the alleles tested were not statistically different among groups

Indentifier

Reference