LongevityMap Gene
Gene details
- HGNC symbol
- HECW1
- Aliases
- NEDL1
- Common name
- HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
- Description
- Cytogenetic Location
- 7p14.1-p13
- UCSC Genome Browser
- View 7p14.1-p13 on the UCSC genome browser
- OMIM
- 610384
- Ensembl
- ENSG00000002746
- UniProt/Swiss-Prot
- HECW1_HUMAN
- Entrez Gene
- 23072
- UniGene
- 164453
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- hecw-1
- Danio rerio
- si:ch211-188f17.1
- Drosophila melanogaster
- CG42797
- Mus musculus
- Hecw1
- Rattus norvegicus
- Hecw1
- Saccharomyces cerevisiae
- RSP5
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
- Conclusions
- No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.
- Indentifier
- rs886550
- Reference