LongevityMap Gene

Gene details

HGNC symbol: GSTT1
Aliases
Common name: glutathione S-transferase theta 1
Description: The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Cytogenetic Location: 22q11.23
UCSC Genome Browser: View 22q11.23 on the UCSC genome browser
OMIM: 600436
Ensembl
UniProt/Swiss-Prot: A0A0G2JRN4_HUMAN
Entrez Gene: 2952
UniGene: 268573
1000 Genomes: 1000 Genomes

Homologs in model organisms

No homologs found

Studies (4)

Significant/Non-significant: 3/1

Study 1

Longevity Association

Population

Italian (Northern)

Study Design

Deletion was examined in 94 nonagenarians and centenarians and 418 control subjects of younger age

Conclusions

A significant difference in the proportion of nonagenarians and centenarians homozygotes for the deletion was observed in comparison to control subjects

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Study Design

Deletion was examined in 205 octogenarians and a reference group of 294 persons aged less than 80 years

Conclusions

Octogenarians had slightly less GSTT1 deficient genotypes

Indentifier

Reference

Study 3

Longevity Association

Population

Study Design

Deletion polymorphism was examined in a longitudinal study of 681 elderly Danish twins (234 men and 447 women)

Conclusions

Both heterozygosity and homozygosity for the GSTT1 functional gene were associated with a moderate but significant increased mortality in women

Indentifier

Reference

Study 4

Longevity Association

Population

Italian (Northern)

Study Design

GSTT1 (Glutathione S-transferase theta 1) deletion and the simultaneous presence of the three p53 polymorphisms were examined in 66 nonagenarians and centenarians in good health and in a sample of 150 young healthy volunteers of the same ethnic group

Conclusions

No significant differences were found for individual genes. However, the absence of any p53 polymorphisms and of GSTT1 deletion, and the simultaneous presence of the three p53 polymorphisms and of GSTT1 deletion, were much more frequent in young subjects than in centenarians (41.5% versus 26.9% and 8.8% versus 3.8%, respectively).

Indentifier

Reference