LongevityMap Gene
Gene details
- HGNC symbol
- GSTM3
- Aliases
- GST5; GSTB; GTM3; GSTM3-3
- Common name
- glutathione S-transferase mu 3
- Description
- Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
- Cytogenetic Location
- 1p13.3
- UCSC Genome Browser
- View 1p13.3 on the UCSC genome browser
- OMIM
- 138390
- Ensembl
- ENSG00000134202
- UniProt/Swiss-Prot
- GSTM3_HUMAN
- Entrez Gene
- 2947
- UniGene
- 2006
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- gst-23
- Caenorhabditis elegans
- gst-41
- Caenorhabditis elegans
- gst-1
- Caenorhabditis elegans
- gst-25
- Danio rerio
- gstm.2
- Danio rerio
- gstm.3
- Danio rerio
- gstm.1
- Mus musculus
- Gstm5
- Rattus norvegicus
- NEWGENE_620381
- Rattus norvegicus
- NEWGENE_620381
- Rattus norvegicus
- Gstm5
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Indentifier
- rs10735234
- Reference