LongevityMap Gene
Gene details
- HGNC symbol
- GRWD1
- Aliases
- CDW4; GRWD; RRB1; WDR28
- Common name
- glutamate rich WD repeat containing 1
- Description
- This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]
- Cytogenetic Location
- 19q13.33
- UCSC Genome Browser
- View 19q13.33 on the UCSC genome browser
- OMIM
- 610597
- Ensembl
- ENSG00000105447
- UniProt/Swiss-Prot
- GRWD1_HUMAN
- Entrez Gene
- 83743
- UniGene
- 400625
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- Y54H5A.1
- Danio rerio
- grwd1
- Drosophila melanogaster
- l(2)09851
- Mus musculus
- Grwd1
- Rattus norvegicus
- Grwd1
- Saccharomyces cerevisiae
- RRB1
- Schizosaccharomyces pombe
- rrb1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
- Conclusions
- No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.
- Indentifier
- rs2302951
- Reference