LongevityMap Gene
Gene details
- HGNC symbol
- GRIN2B
- Aliases
- MRD6; NR2B; hNR3; EIEE27; GluN2B; NMDAR2B
- Common name
- glutamate ionotropic receptor NMDA type subunit 2B
- Description
- N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 12p13.1
- UCSC Genome Browser
- View 12p13.1 on the UCSC genome browser
- OMIM
- 138252
- Ensembl
- ENSG00000273079
- UniProt/Swiss-Prot
- NMDE2_HUMAN
- Entrez Gene
- 2904
- UniGene
- 504844
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- GRIN2B (1 of many)
- Danio rerio
- grin2bb
- Mus musculus
- Grin2b
- Rattus norvegicus
- Grin2b
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- European
- Study Design
- Meta-analysis of genome-wide association studies of survival and survival free of major disease or death. In total, there were 25,007 participants over 55 years of age and followed-up for over 10 years for mortality and over 8 years for event-free survival.
- Conclusions
- No SNP was significantly associated with time to event after correcting for multiple testing, but 8 independent SNPs predicted event-free survival at a suggestive threshold
- Indentifier
- rs4764043
- Reference