LongevityMap Gene
Gene details
- HGNC symbol
- GRIA4
- Aliases
- GLUR4; GLURD; GluA4; GLUR4C
- Common name
- glutamate ionotropic receptor AMPA type subunit 4
- Description
- Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 11q22.3
- UCSC Genome Browser
- View 11q22.3 on the UCSC genome browser
- OMIM
- 138246
- Ensembl
- ENSG00000152578
- UniProt/Swiss-Prot
- GRIA4_HUMAN
- Entrez Gene
- 2893
- UniGene
- 503743
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- glr-2
- Caenorhabditis elegans
- glr-1
- Danio rerio
- gria4a
- Danio rerio
- gria4b
- Drosophila melanogaster
- GluRIB
- Drosophila melanogaster
- GluRIA
- Mus musculus
- Gria4
- Rattus norvegicus
- Gria4
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Some signals were at best tentative but may merit study in larger sample sets
- Indentifier
- rs680109
- Reference