LongevityMap Gene
Gene details
- HGNC symbol
- GRIA1
- Aliases
- GLUH1; GLUR1; GLURA; GluA1; HBGR1
- Common name
- glutamate ionotropic receptor AMPA type subunit 1
- Description
- Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 5q33.2
- UCSC Genome Browser
- View 5q33.2 on the UCSC genome browser
- OMIM
- 138248
- Ensembl
- ENSG00000155511
- UniProt/Swiss-Prot
- GRIA1_HUMAN
- Entrez Gene
- 2890
- UniGene
- 519693
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- glr-2
- Caenorhabditis elegans
- glr-1
- Danio rerio
- gria1a
- Danio rerio
- gria1b
- Drosophila melanogaster
- GluRIB
- Drosophila melanogaster
- GluRIA
- Mus musculus
- Gria1
- Rattus norvegicus
- Gria1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- European
- Study Design
- Meta-analysis of genome-wide association studies of survival and survival free of major disease or death. In total, there were 25,007 participants over 55 years of age and followed-up for over 10 years for mortality and over 8 years for event-free survival.
- Conclusions
- No SNP was significantly associated with time to event after correcting for multiple testing, but 8 independent SNPs predicted event-free survival at a suggestive threshold
- Indentifier
- rs3112530
- Reference