LongevityMap Gene
Gene details
- HGNC symbol
- GPC6
- Aliases
- OMIMD1
- Common name
- glypican 6
- Description
- The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]
- Cytogenetic Location
- 13q31.3-q32.1
- UCSC Genome Browser
- View 13q31.3-q32.1 on the UCSC genome browser
- OMIM
- 604404
- Ensembl
- ENSG00000183098
- UniProt/Swiss-Prot
- GPC6_HUMAN
- Entrez Gene
- 10082
- UniGene
- 444329
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- gpn-1
- Danio rerio
- CABZ01086393.1
- Danio rerio
- gpc6a
- Danio rerio
- gpc6b
- Drosophila melanogaster
- dlp
- Mus musculus
- Gpc6
- Rattus norvegicus
- Gpc6
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs17702471
- Reference