LongevityMap Gene
Gene details
- HGNC symbol
- GLRX
- Aliases
- GRX; GRX1
- Common name
- glutaredoxin
- Description
- This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
- Cytogenetic Location
- 5q15
- UCSC Genome Browser
- View 5q15 on the UCSC genome browser
- OMIM
- 600443
- Ensembl
- ENSG00000173221
- UniProt/Swiss-Prot
- A0A024RAM2_HUMAN
- Entrez Gene
- 2745
- UniGene
- 28988
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- glrx-10
- Danio rerio
- glrx
- Mus musculus
- Glrx
- Rattus norvegicus
- AC243283.1
- Rattus norvegicus
- AC242890.1
- Rattus norvegicus
- AC244836.1
- Rattus norvegicus
- Glrx
- Rattus norvegicus
- AC240814.1
- Rattus norvegicus
- LOC305806
- Rattus norvegicus
- AC242886.1
- Rattus norvegicus
- AC241705.1
- Rattus norvegicus
- AC241562.1
- Rattus norvegicus
- AC241244.1
- Rattus norvegicus
- AC242860.1
- Rattus norvegicus
- AC241717.1
- Rattus norvegicus
- AC242583.1
- Rattus norvegicus
- AC241930.1
- Rattus norvegicus
- AC242273.1
- Rattus norvegicus
- AC242259.1
- Saccharomyces cerevisiae
- GRX2
- Saccharomyces cerevisiae
- GRX1
In other databases
- CellAge gene expression
- This gene is present as GLRX
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Indentifier
- rs1047420
- Reference