LongevityMap Gene

Gene details

HGNC symbol: GHRHR
Aliases: GRFR; GHRFR; IGHD1B
Common name: growth hormone releasing hormone receptor
Description: This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]
Cytogenetic Location: 7p14.3
UCSC Genome Browser: View 7p14.3 on the UCSC genome browser
OMIM: 139191
Ensembl: ENSG00000106128
UniProt/Swiss-Prot: A0A090N8Y6_HUMAN
Entrez Gene: 2692
UniGene: 767
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: ghrhrl
Mus musculus: Ghrhr
Rattus norvegicus: Ghrhr

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Ghrhr

GenAge human genes

This gene is present as GHRHR

Studies (3)

Significant/Non-significant: 1/2

Study 1

Longevity Association

Non-significant

Population

Study Design

Codon 57 A/G SNP was examined in 1576 individuals aged 85 and older

Conclusions

No association with longevity was found

Indentifier

Reference

Study 2

Longevity Association: Significant
Population: Danish
Study Design: Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
Conclusions: Eleven SNPs (in GSR, KL, GHRHR, INS, GHSR, IGF2R, RAD52, WRN, RAD23B, POLB and NTLH1) were associated with longevity after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
Indentifier

Study 3

Longevity Association: Non-significant
Population: American (Caucasian)
Study Design: 291 SNPs in 30 genes in the insulin/IGF1 signaling pathway were evaluated in 293 long-lived cases and 603 average-lifespan controls (all female), then replicated the candidate genes in two independent cohorts: 279 cases (47% male vs 797 controls(52.6% male) and 383 cases (25.2% male) vs 363 controls (42.7 % male)
Conclusions: Apart SNPs in FOXO3A and AKT1, no associations with longevity were significant after correcting for multiple testing, though SNPs in 7 other genes (FOXO1A, GHR, GHRHR, IGF1R, IGFBP3, IGFBP4, and PTEN) had suggestive significance
Indentifier