LongevityMap Gene
Gene details
- HGNC symbol
- GC
- Aliases
- DBP; GRD3; VDBG; VDBP; GcMAF; DBP/GC; Gc-MAF; HEL-S-51
- Common name
- GC, vitamin D binding protein
- Description
- The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
- Cytogenetic Location
- 4q13.3
- UCSC Genome Browser
- View 4q13.3 on the UCSC genome browser
- OMIM
- 139200
- Ensembl
- ENSG00000145321
- UniProt/Swiss-Prot
- VTDB_HUMAN
- Entrez Gene
- 2638
- UniGene
- 418497
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- Single nucleotide polymorphisms (SNPs) associated with vitamin D levels were studied in the offspring (n = 1038) of nonagenarians who had at least one nonagenarian sibling. The offsprings' partners (n = 461) were used as controls.
- Conclusions
- No SNP was found to be associated with longevity after correcting for multiple testing, though the offspring had a slightly lower frequency of a genetic variant (rs2060793) in CYP2R1
- Indentifier
- rs2282679
- Reference