LongevityMap Gene
Gene details
- HGNC symbol
- FTO
- Aliases
- GDFD; ALKBH9; BMIQ14
- Common name
- FTO, alpha-ketoglutarate dependent dioxygenase
- Description
- This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
- Cytogenetic Location
- 16q12.2
- UCSC Genome Browser
- View 16q12.2 on the UCSC genome browser
- OMIM
- 610966
- Ensembl
- ENSG00000140718
- UniProt/Swiss-Prot
- A0A1B0GTC5_HUMAN
- Entrez Gene
- 79068
- UniGene
- 528833
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- A set of alleles associated with age-related diseases was tested for association with human longevity in 723 nonagenarian siblings and 721 unrelated younger controls plus 979 singleton individuals >85 years of age and 1,167 younger controls
- Conclusions
- No differences were observed in disease risk allele frequency between long-lived individuals and controls. No individual allele was significantly associated with survival to old age after controlling for multiple testing.
- Indentifier
- rs8050136
- Reference