LongevityMap Gene
Gene details
- HGNC symbol
- FMN2
- Aliases
- Common name
- formin 2
- Description
- This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. Mutations in this gene have been associated with mental retardation autosomal recessive 47 (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
- Cytogenetic Location
- 1q43
- UCSC Genome Browser
- View 1q43 on the UCSC genome browser
- OMIM
- 606373
- Ensembl
- ENSG00000155816
- UniProt/Swiss-Prot
- FMN2_HUMAN
- Entrez Gene
- 56776
- UniGene
- 24889
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
- Conclusions
- A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
- Indentifier
- rs12088486
- Reference