LongevityMap Gene

Gene details

HGNC symbol: FHIT
Aliases: FRA3B; AP3Aase
Common name: fragile histidine triad
Description: This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Cytogenetic Location: 3p14.2
UCSC Genome Browser: View 3p14.2 on the UCSC genome browser
OMIM: 601153
Ensembl: ENSG00000189283
UniProt/Swiss-Prot: A0A024R366_HUMAN
Entrez Gene: 2272
UniGene: 655995
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: FHIT (1 of many)
Danio rerio: fhit
Mus musculus: Fhit
Saccharomyces cerevisiae: HNT2

Studies (1)

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

Reference