LongevityMap Gene
Gene details
- HGNC symbol
- FGB
- Aliases
- HEL-S-78p
- Common name
- fibrinogen beta chain
- Description
- The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
- Cytogenetic Location
- 4q31.3
- UCSC Genome Browser
- View 4q31.3 on the UCSC genome browser
- OMIM
- 134830
- Ensembl
- ENSG00000171564
- UniProt/Swiss-Prot
- FIBB_HUMAN
- Entrez Gene
- 2244
- UniGene
- 300774
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (4)
Significant/Non-significant: 0/4
Study 1
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- The G/A-455 SNP was examined in 124 healthy individuals over 100 years old and 130 young, healthy individuals
- Conclusions
- Alleles and genotypes were found with similar frequencies in centenarians and in the control group
- Indentifier
- -455G/A
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- The -455G/A SNP was examined in 187 centenarians and 201 healthy controls aged 20-64 years (mean age 42 years)
- Conclusions
- The genotype frequencies in the centenarians and the controls were similar
- Indentifier
- -455G/A
- Reference
Study 3
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- The G/A-455 SNP was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years)
- Conclusions
- No association with longevity was found
- Indentifier
- -455G/A
- Reference
Study 4
- Longevity Association
- Non-significant
- Population
- American (Caucasian)
- Study Design
- Genotypes for -455 G/A were studied in 2224 men and women aged 65 years and older at baseline
- Conclusions
- During 10 years of follow-up, no association with survival was found
- Indentifier
- -455G/A
- Reference