LongevityMap Gene
Gene details
- HGNC symbol
- FEN1
- Aliases
- MF1; RAD2; FEN-1
- Common name
- flap structure-specific endonuclease 1
- Description
- The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 11q12.2
- UCSC Genome Browser
- View 11q12.2 on the UCSC genome browser
- OMIM
- 600393
- Ensembl
- ENSG00000168496
- UniProt/Swiss-Prot
- FEN1_HUMAN
- Entrez Gene
- 2237
- UniGene
- 409065
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- crn-1
- Danio rerio
- fen1
- Mus musculus
- Fen1
- Rattus norvegicus
- Fen1
- Saccharomyces cerevisiae
- RAD27
- Schizosaccharomyces pombe
- rad2
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RAD27
- GenAge human genes
- This gene is present as FEN1
- CellAge gene expression
- This gene is present as FEN1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs695867
- Reference