LongevityMap Gene

Gene details

HGNC symbol: FASTKD3
Aliases
Common name: FAST kinase domains 3
Description: This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Cytogenetic Location: 5p15.31
UCSC Genome Browser: View 5p15.31 on the UCSC genome browser
OMIM
Ensembl: ENSG00000124279
UniProt/Swiss-Prot: FAKD3_HUMAN
Entrez Gene: 79072
UniGene: 653162
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: fastkd3
Mus musculus: Fastkd3
Rattus norvegicus: Fastkd3

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Caucasians

Study Design

Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).

Conclusions

There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing

Indentifier

rs16879258

Reference