LongevityMap Gene
Gene details
- HGNC symbol
- FARP1
- Aliases
- CDEP; PLEKHC2; PPP1R75; FARP1-IT1
- Common name
- FERM, ARH/RhoGEF and pleckstrin domain protein 1
- Description
- This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
- Cytogenetic Location
- 13q32.2
- UCSC Genome Browser
- View 13q32.2 on the UCSC genome browser
- OMIM
- 602654
- Ensembl
- ENSG00000152767
- UniProt/Swiss-Prot
- C9JME2_HUMAN
- Entrez Gene
- 10160
- UniGene
- 403917
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- frm-3
- Danio rerio
- farp1
- Drosophila melanogaster
- Cdep
- Mus musculus
- Farp1
- Rattus norvegicus
- Farp1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
- Conclusions
- A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
- Indentifier
- rs285097
- Reference