LongevityMap Gene
Gene details
- HGNC symbol
- FAM19A1
- Aliases
- TAFA1; TAFA-1
- Common name
- family with sequence similarity 19 member A1, C-C motif chemokine like
- Description
- This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 3p14.1
- UCSC Genome Browser
- View 3p14.1 on the UCSC genome browser
- OMIM
- Ensembl
- ENSG00000183662
- UniProt/Swiss-Prot
- F19A1_HUMAN
- Entrez Gene
- 407738
- UniGene
- 655061
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Some signals were at best tentative but may merit study in larger sample sets
- Indentifier
- rs17047650
- Reference